Fig. 1 · Structure
Documents & Downloads
PDE4B/7A-IN-1
Phosphodiesterase Inhibitor
PDE4B/7A-IN-1 is a dual inhibitor of phosphodiesterase 4B (PDE4B) and phosphodiesterase 7A (PDE7A), demonstrating an IC50 of 80.4 μM for PDE4B. This compound also acts as an antagonist for 5-HT1A and 5-HT7 receptors, providing insight into its potential antidepressant effects. With good membrane penetration and high metabolic stability, PDE4B/7A-IN-1 serves as a valuable tool for studying neuropharmacology and antidepressant mechanisms in preclinical models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2511632-25-8 |
| Applications | Phosphodiesterase Inhibitor |
| Formula | C25H35N3O3 |
| Molecular Weight | 425.56 |
| SMILES | COC1=C(C=CC=C1)N2CCN(CC2)CCCC(NC3=CC(C(C)(C)C)=CC=C3O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.