Fig. 1 · Structure
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PDE4B/7A-IN-2
Phosphodiesterase Inhibitor
PDE4B/7A-IN-2 is a selective phosphodiesterase inhibitor targeting PDE4B and PDE7A. It exhibits notable inhibitory activity with IC50 values of 80.4 μM for PDE4B and 151.3 μM for PDE7A. Additionally, this compound serves as a 5-HT1A and 5-HT7 receptor antagonist, demonstrating a Ki of 8 nM for 5-HT1A and 451 nM for 5-HT7. Its antidepressant-like effects suggest potential applications in research focused on mood disorders and signaling pathways involved in neuropharmacology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2511632-55-4 |
| Applications | Phosphodiesterase Inhibitor |
| Formula | C25H35N3O2 |
| Molecular Weight | 409.56 |
| SMILES | COC1=C(C=CC=C1)N2CCN(CC2)CCCCC(NC3=CC=C(C=C3)C(C)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.