Fig. 1 · Structure
Documents & Downloads
PDGFRα kinase inhibitor 2
Kinase Inhibitor
PDGFRα Kinase Inhibitor 2 is a covalent and irreversible inhibitor targeting the PDGF receptor alpha (PDGFRα) and associated kinases such as ABL1 and KIT. With IC50 values of 6.95 μM for ABL1 wt, 2.45 μM for KIT wt, and 1.39 μM for PDGFRα wt, this compound demonstrates significant potency. It is primarily used in research focused on therapeutic strategies for diseases characterized by aberrant PDGFR signaling, including certain cancers and fibrotic disorders.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 404844-11-7 |
| Applications | Kinase Inhibitor |
| Formula | C24H20ClN5O |
| Molecular Weight | 429.90 |
| SMILES | O=C(C1=CC=C(CCl)C=C1)NC2=CC=C(C)C(NC3=NC(C4=CN=CC=C4)=CC=N3)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.