Fig. 1 · Structure
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PDHK-IN-7
pyruvate dehydrogenase kinase inhibitor
PDHK-IN-7 is a potent inhibitor of pyruvate dehydrogenase kinase, exhibiting an IC50 value of 17 nM. This compound effectively activates pyruvate dehydrogenase (PDH) in rat liver tissue, leading to enhanced glucose metabolism. Additionally, PDHK-IN-7 demonstrates a significant glucose-lowering effect in Zucker fatty rats, making it a valuable reagent for research in metabolic disorders and diabetes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1220965-73-0 |
| Applications | pyruvate dehydrogenase kinase inhibitor |
| Formula | C20H17F3N2O2 |
| Molecular Weight | 374.36 |
| SMILES | CC1=CC2=C(C3=CC=CC=C3C2(O)C(F)(F)F)C(C4=CN(CCO)N=C4)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.