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PDHK1-IN-2

PDHK1/2 Inhibitor

PDHK1-IN-2 is a potent ATP-competitive inhibitor targeting pyruvate dehydrogenase kinases 1 and 2 (PDHK1/2), exhibiting IC50 values of 0.007 μM and 0.015 μM, respectively. This inhibitor has been shown to modulate immune cell metabolism and restore mitochondrial function, making it a valuable tool for investigating autoimmune disorders, inflammatory diseases, and various types of cancer. Its ability to influence metabolic pathways positions PDHK1-IN-2 as a significant compound for research in related fields.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2870691-38-4
Applications	PDHK1/2 Inhibitor
Formula	C₂₅H₃₃FN₆O₂
Molecular Weight	468.57
SMILES	CCNC1=CC(F)=CC(C2(CC)N3CCC[C@@H](NC(C4CC5(CN(C#N)C5)C4)=O)C3)=C1NC2=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.