Fig. 1 · Structure
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Peldesine dihydrochloride
Purine Nucleoside Phosphorylase Inhibitor
Peldesine dihydrochloride is a potent and selective inhibitor of purine nucleoside phosphorylase (PNP), demonstrating competitive and reversible inhibition with IC50 values of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell PNP, respectively. Additionally, it inhibits T-cell proliferation with an IC50 of 800 nM. This compound is valuable for research applications related to cutaneous T-cell lymphoma, psoriasis, and HIV infection.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2772702-10-8 |
| Applications | Purine Nucleoside Phosphorylase Inhibitor |
| Formula | C12H13Cl2N5O |
| Molecular Weight | 314.17 |
| Synonyms | BCX 34 dihydrochloride |
| SMILES | Cl[H].O=C1C(NC=C2CC3=CC=CN=C3)=C2N=C(N)N1.Cl[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.