Pellotine is an alkaloid that acts as an inverse agonist targeting the 5-HT7 receptor, exhibiting an EC50 of 291 nM. This compound also demonstrates significant affinity for the 5-HT1DR and 5-HT6R receptors, with Ki values of 117 nM and 170 nM, respectively. Pellotine effectively decreases intracellular cAMP levels, leading to reduced neuronal excitability and neurotransmitter release, making it a valuable tool for research into neuropharmacology and serotonergic signaling pathways.
Pellotine is an alkaloid that acts as an inverse agonist targeting the 5-HT7 receptor, exhibiting an EC50 of 291 nM. This compound also demonstrates significant affinity for the 5-HT1DR and 5-HT6R receptors, with Ki values of 117 nM and 170 nM, respectively. Pellotine effectively decreases intracellular cAMP levels, leading to reduced neuronal excitability and neurotransmitter release, making it a valuable tool for research into neuropharmacology and serotonergic signaling pathways.
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