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Pellotine

5-HT7 Receptor Antagonist

Pellotine is an alkaloid that acts as an inverse agonist targeting the 5-HT7 receptor, exhibiting an EC50 of 291 nM. This compound also demonstrates significant affinity for the 5-HT1DR and 5-HT6R receptors, with Ki values of 117 nM and 170 nM, respectively. Pellotine effectively decreases intracellular cAMP levels, leading to reduced neuronal excitability and neurotransmitter release, making it a valuable tool for research into neuropharmacology and serotonergic signaling pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inverse Agonist
CAS Number	19622-05-0
Applications	5-HT7 Receptor Antagonist
Formula	C₁₃H₁₉NO₃
Molecular Weight	237.29
SMILES	COC1=C(OC)C(O)=C(C(C)N(C)CC2)C2=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.