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Pembrolizumab (anti-PD-1)
Pembrolizumab is a humanized IgG4 monoclonal antibody that functions as a programmed death-1 (PD-1) inhibitor. It effectively blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2. This inhibition prevents the suppression of T-cell activity, typically mediated by PD-1 signaling in cells expressing these ligands, thereby enhancing the immune response against tumor cells. Pembrolizumab is utilized extensively in immunotherapy protocols for various cancers, leveraging its ability to modulate immune system responses.
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Product Details
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| Molecular Weight | 146341 |
| Synonyms | MK-3475 (anti-PD-1; Lambrolizumab (anti-PD-1 |
Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.