Fig. 1 · Structure
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Pentacosafluorotridecanoic Acid
TSH Receptor
Pentacosafluorotridecanoic Acid primarily targets the TSH receptor and is classified as a perfluoroalkyl substance (PFAS). It demonstrates significant biological activity by inducing yolk sac edema and increasing mRNA expression of thyroid hormone synthesis genes, such as tshβ, in zebrafish at concentrations of 0.1 and 0.3 mg/L. Additionally, in rat models, administration of Pentacosafluorotridecanoic Acid at 10 mg/kg results in decreased serum testosterone and luteinizing hormone levels, alteration of fatty acid profiles in the testis, and a reduction in Leydig cell numbers during late puberty. Its presence in maternal plasma has been correlated with the development of eczema in female infants, and higher levels have been observed in cancerous human livers compared to non-cancerous tissues.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 72629-94-8 |
| Applications | TSH Receptor |
| Formula | C₁₃HF₂₅O₂ |
| Molecular Weight | 664.11 |
| Synonyms | PFTrDA |
| SMILES | OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.