Fig. 1 · Structure
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pep2-SVKI
GluA2-GRIP/ABP/PICK1 Inhibitor
pep2-SVKI is a selective peptide inhibitor targeting the C-terminal PDZ site of the AMPA-type glutamate receptor GluA2. This compound disrupts the interaction between GluA2 and glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP), and C-kinase interacting protein (PICK1), leading to enhanced AMPA receptor-mediated current amplitude and inhibition of long-term depression (LTD). pep2-SVKI serves as a valuable tool for investigating the molecular mechanisms underlying neurological diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 328944-75-8 |
| Applications | GluA2-GRIP/ABP/PICK1 Inhibitor |
| Formula | C60H93N13O18 |
| Molecular Weight | 1284.46 |
| SMILES | [C@@H](CC1=CC=C(O)C=C1)(NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)N)=O)CC(N)=O)=O)[C@@H](C)C)=O)C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@H](CC)C)C(O)=O)=O)CCCCN)=O)C(C)C)=O)CO)=O)CCC(O)=O)=O)[C@H](CC)C)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.