Fig. 1 · Structure
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Pep2m
NSF-GluR2 Receptor Inhibitor
Pep2m is a peptide-based inhibitor targeting the N-ethylmaleimide-sensitive fusion protein (NSF) interaction with the C-terminus of the AMPA-type glutamate receptor subunit GluA2. By inhibiting this interaction, Pep2m effectively prevents synaptic long-term depression (LTD), leading to a reduction in postsynaptic currents and AMPA-mediated currents in cultured hippocampal neurons. Additionally, it decreases the surface expression of AMPA receptors, making it a valuable tool for studies on synaptic transmission and plasticity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 243843-42-7 |
| Applications | NSF-GluR2 Receptor Inhibitor |
| Formula | C49H92N18O13S |
| Molecular Weight | 1173.43 |
| SMILES | CSCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.