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Peretinoin, also known as NIK-333 , orally available, acyclic retinoid with potential antineoplastic and chemopreventive activities. Peretinoin binds to and activates nuclear retinoic acid receptors (RAR), which in turn recruit coactivator proteins and promote, with other transcriptional complexes, the transcription of target genes. As a result, this agent may modulate the expression of genes involved in the regulation of cell proliferation, cell differentiation, and apoptosis of both normal and tumor cells.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.06 mL | 165.32 mL | 330.63 mL |
| 0.5 mM | 6.61 mL | 33.06 mL | 66.13 mL |
| 1 mM | 3.31 mL | 16.53 mL | 33.06 mL |
| 5 mM | 0.66 mL | 3.31 mL | 6.61 mL |
*The above data is based on the productmolecular weight 302.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18229 |
|---|---|
| CAS No. | 81485-25-8 |
| Formula | C20H30O2 |
| M. Wt | 302.45 |
| Purity | >98% |
| Synonyms | Peretinoin; NIK333 |
| SMILES | C/C(C)=C/CC/C(C)=C/CC/C(C)=C/C=C/C(C)=C/C(O)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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