Fig. 1 · Structure
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PF-00489791
Phosphodiesterase 5A Inhibitor
PF-00489791 is a potent phosphodiesterase 5A (PDE5A) inhibitor, demonstrating an IC50 of 1.5 nM. This compound enhances vascular relaxation in the kidneys, leading to reduced blood pressure and improved renal function. PF-00489791 is valuable for research applications focused on cardiovascular health, renal physiology, and related therapeutic investigations.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 853003-48-2 |
| Applications | Phosphodiesterase 5A Inhibitor |
| Formula | C20H28N8O4S |
| Molecular Weight | 476.55 |
| Synonyms | PF-489791 |
| SMILES | O=C(C1=NN(CCOCC)C2=C1N=C(N(CC)C)N=C2NC3=NC=CC(C)=C3)NS(=O)(C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.