Fig. 1 · Structure
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PF-03382792
5-HT4 Partial Agonist
PF-03382792 is a potent partial agonist of the 5-HT4 receptor, exhibiting a Ki value of 2.7 nM and an EC50 of 0.9 nM for the 5-HT4d subtype. This compound demonstrates the ability to penetrate the blood-brain barrier and has been shown to elicit moderate increases in cortical acetylcholine levels in the rat prefrontal cortex. PF-03382792 is a valuable tool for research investigating cognitive processes and potential therapeutic strategies for neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Partial Agonist |
| CAS Number | 1400811-63-3 |
| Applications | 5-HT4 Partial Agonist |
| Formula | C23H32FN3O4 |
| Molecular Weight | 433.52 |
| SMILES | O=C(N1C(C(C)(C)C2=C1C=C(F)C=C2)=O)NCC3CCN(CC4(O)CCOCC4)CC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.