Fig. 1 · Structure
Documents & Downloads
PF-03622905
PKC Inhibitor
PF-03622905 is a highly selective, ATP-competitive inhibitor of protein kinase C (PKC) isoforms, demonstrating IC50 values of 5.6 nM for PKCα, 14.5 nM for PKCβI, 13 nM for PKCβII, 37.7 nM for PKCγ, and 74.1 nM for PKCθ. This compound exhibits strong specificity for PKC, making it a valuable tool for research applications focused on cell signaling pathways, cancer biology, and therapeutic development targeting PKC-related diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1072100-15-2 |
| Applications | PKC Inhibitor |
| Formula | C24H35N7O3 |
| Molecular Weight | 469.58 |
| SMILES | O=C(C1=CC=CC=N1)NC2=NNC3=C2CN(C(N4C[C@H](N(C[C@@H]4C)CCC)CCO)=O)C3(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.