Fig. 1 · Structure
Documents & Downloads
PF-04279405
Glucokinase Agonist
PF-04279405 is a potent glucokinase (GK) agonist with an EC50 of 23 nM. Glucokinase is crucial for glucose metabolism, facilitating the conversion of glucose to glucose-6-phosphate and contributing to glucose homeostasis. This compound is valuable for research applications targeting type 2 diabetes, offering insights into therapeutic mechanisms and metabolic regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 955881-01-3 |
| Applications | Glucokinase Agonist |
| Formula | C25H25FN4O4 |
| Molecular Weight | 464.49 |
| SMILES | O=C(C1=CC(OC2=CC=C(C(N3CCC3)=O)C(F)=C2)=C4CC(C)(C)OC4=C1)NC5=NN(C)C=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.