Glasdegib (PF-04449913)

Name: Glasdegib (PF-04449913)
SKU: A13881
Price: 72 USD
Rating: 5 (288 reviews)

Catalog No.: A13881

Smoothened inhibitor

PF-04449913 is a potent and orally bioavailable inhibitor of smoothened.

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Grouped product items
Product Name	Price	Stock
Glasdegib (PF-04449913) 5mg	Special Price $72.00 Regular Price $90.00	In stock
Glasdegib (PF-04449913) 10mg	Special Price $128.00 Regular Price $160.00	In stock
Glasdegib (PF-04449913) 25mg	Special Price $256.00 Regular Price $320.00	In stock
*Glasdegib (PF-04449913) 10mM 1mL in DMSO**	Special Price $100.80 Regular Price $126.00	In stock
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Data Sheet

SDS

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Biological Activity

Discription

PF-04449913 is a potent and orally bioavailable inhibitor of smoothened.

Targets

Target	Value

Product Information

Catalog Num	A13881
Formula	C21H22N6O
Molecular Weight	374.18
CAS Number	1095173-27-5
SMILES	CN1CC[C@H](C[C@@H]1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N
Synonyms	PF-4449913,PF04449913
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro	DMSO	46 mg/mL (122.85 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.73 mL	133.63 mL	267.25 mL
0.5 mM	5.35 mL	26.73 mL	53.45 mL
1 mM	2.67 mL	13.36 mL	26.73 mL
5 mM	0.53 mL	2.67 mL	5.35 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂