Glasdegib (PF-04449913)

Catalog No.: A13881

Smoothened inhibitor

Glasdegib (PF-04449913)

Glasdegib (PF-04449913) Chemical Structure

CAS NO. 1095173-27-5

PF-04449913 is a potent and orally bioavailable inhibitor of smoothened.

Availability: In stock

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5 mg
10 mg
25 mg
10mM * 1mL in DMSO
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Biological Activity

PF-04449913 is a potent and orally bioavailable inhibitor of smoothened.
5 nM
In vitro DMSO 46 mg/mL (122.85 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.73 mL 133.63 mL 267.25 mL
0.5 mM 5.35 mL 26.73 mL 53.45 mL
1 mM 2.67 mL 13.36 mL 26.73 mL
5 mM 0.53 mL 2.67 mL 5.35 mL

*The above data is based on the productmolecular weight 374.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13881
Actions Inhibitor
CAS No. 1095173-27-5
Formula C21H22N6O
M. Wt 374.18
Solubility DMSO
Purity >98%
Synonyms PF-4449913,PF04449913
SMILES CN1CC[[email protected]](C[[email protected]@H]1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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