Target & Activity
| Target | Activity | Value |
|---|---|---|
| Rat CCR2 | IC50 | 20.8 nM |
| CCR5 | IC50 | 470 nM |
Fig. 1 · Structure
Documents & Downloads
PF-04634817
CCR2 /CCR5 dual antagonist
PF-04634817 is an orally administered CCR2 and CCR5 chemokine receptor antagonist, for the treatment of diabetic nephropathies and diabetic macular oedema.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1228111-63-4 |
| Applications | CCR2 /CCR5 dual antagonist |
| Formula | C25H36F3N5O3 |
| Molecular Weight | 511.59 |
| Synonyms | PF-4634817; PF4634817. |
| SMILES | O=C([C@]1(C(C)C)C[C@H](N[C@@H]2[C@H](OC)COCC2)CC1)N3[C@](C4)([H])CN(C5=NC=NC(C(F)(F)F)=C5)[C@]4([H])C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.