PF-04880594

Catalog No.: A12739

RAF inhibitor

PF-04880594

PF-04880594 Chemical Structure

CAS NO. 1111636-35-1

PF-04880594 is an inhibitor of RAF with IC50 values of 0.19 nM/0.13 nM and 0.39 nM for BRAF/BRAFV599E and c-RAF, respectively.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $350.00

Special Price $280.00

10 mg

Regular Price: $650.00

Special Price $520.00

25 mg

Regular Price: $1,200.00

Special Price $960.00

50 mg

Regular Price: $2,000.00

Special Price $1,600.00

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Biological Activity

PF-04880594 is an inhibitor of RAF with IC50 values of 0.19 nM/0.13 nM and 0.39 nM for BRAF/BRAFV599E and c-RAF, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.36 mL 126.78 mL 253.56 mL
0.5 mM 5.07 mL 25.36 mL 50.71 mL
1 mM 2.54 mL 12.68 mL 25.36 mL
5 mM 0.51 mL 2.54 mL 5.07 mL

*The above data is based on the productmolecular weight 394.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12739
Actions Inhibitor
CAS No. 1111636-35-1
Formula C19H16F2N8
M. Wt 394.38
Purity >98%
Synonyms PF-04880594, PF04880594, PF 04880594
SMILES C1=CNC2=NC=C(C=C21)C3=NN(C=C3C4=NC(=NC=C4)NCCC#N)CC(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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