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PF-06422913

mGluR5 Negative Allosteric Modulator

PF-06422913 is a potent and selective negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5). This compound exhibits significant biological activity in modulating glutamatergic signaling, making it valuable in the study of neuropsychiatric disorders. Its applications include investigating therapeutic strategies for conditions such as anxiety and schizophrenia, where mGluR5 activity is implicated.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	1539296-46-2
Applications	mGluR5 Negative Allosteric Modulator
Formula	C₁₈H₁₃F₃N₆O
Molecular Weight	386.33
SMILES	FC(F)(C1=C(C2=NN(C)C3=C2N=CC(OCC4=NC=CC=C4)=N3)C=NC=C1)F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.