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PF-06462894

GluR5 Modulator

PF-06462894 is a negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5). It demonstrates efficacy in modulating mGluR5 activity in both rat and nonhuman primate models. This compound is valuable for investigating the role of mGluR5 in various neurological disorders and can be used in research focused on synaptic transmission and plasticity.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	1622291-66-0
Applications	GluR5 Modulator
Formula	C₁₈H₂₃N₃O₃
Molecular Weight	329.39
SMILES	O=C1C=C(OCC2=CC=CC=N2)N=C3N1[C@H](CC(C)(C)C)COC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.