Catalog No.: A14207

ALK inhibitor


PF-06463922 Chemical Structure

CAS NO. 1454846-35-5

PF-06463922 is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.

Availability: In stock

Package Price Qty
5 mg
10 mg
25 mg
10mM * 1mL in DMSO
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Biological Activity

PF-06463922 is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.
Target Value
ROS1ki: <0.02nM
ROS1ki: <0.02nM
ALKki: <0.07nM
ALK(L1196M)ki: 0.07nM
LTK(TYK1)IC50: 2.7nM
FERIC50: 3.3nM
PTK2B(FAK2)IC50: 14nM
TNK2(ACK)IC50: 17nM
PTK2(FAK)IC50: 17nM
NTRK2(TRKB)ki: 23nM
FRK(PTK5)IC50: 53nM
EGFR(ErbB1)T790ML858RIC50: 245nM
IGF1RIC50: 296nM
STK22B(TSSK2)IC50: 302nM
EGFR(ErbB1)T790MIC50: 319nM
DCAMKL2(DCK2)IC50: 370nM
EPHA1IC50: 375nM
JAK2IC50: 529nM
In vitro (25°C) DMSO Warmed: 70 mg/mL (172.23 mM)
Water Insoluble
Ethanol Warmed: 26 mg/mL
In vivo 2% DMSO+30% PEG 300+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.61 mL 123.03 mL 246.06 mL
0.5 mM 4.92 mL 24.61 mL 49.21 mL
1 mM 2.46 mL 12.3 mL 24.61 mL
5 mM 0.49 mL 2.46 mL 4.92 mL

*The above data is based on the productmolecular weight 406.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14207
Actions Inhibitor
CAS No. 1454846-35-5
Formula C21H19FN6O2
M. Wt 406.41
Purity >98%
Synonyms PF 06463922, PF06463922
SMILES C[[email protected]@H]1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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