PF-06463922

Catalog No.: A14207

ALK inhibitor

PF-06463922 Chemical Structure

CAS NO. 1454846-35-5

PF-06463922 is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$90.00
25 mg
$150.00
10mM * 1mL in DMSO
$66.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PF-06463922 is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.
Targets
Target Value
ROS1ki: <0.02nM
ROS1ki: <0.02nM
ALKki: <0.07nM
ALK(L1196M)ki: 0.07nM
LTK(TYK1)IC50: 2.7nM
FERIC50: 3.3nM
FES(FPS)IC50: 6nM
PTK2B(FAK2)IC50: 14nM
TNK2(ACK)IC50: 17nM
PTK2(FAK)IC50: 17nM
NTRK2(TRKB)IC50: 23nM
NTRK2(TRKB)ki: 23nM
NTRK1(TRKA)IC50: 24nM
NTRK3(TRKC)IC50: 46nM
FRK(PTK5)IC50: 53nM
EGFR(ErbB1)T790ML858RIC50: 245nM
IGF1RIC50: 296nM
STK22B(TSSK2)IC50: 302nM
EGFR(ErbB1)T790MIC50: 319nM
DCAMKL2(DCK2)IC50: 370nM
EPHA1IC50: 375nM
JAK2IC50: 529nM
In vitro DMSO 81 mg/mL (199.3 mM)
Water <1 mg/mL (<1 mM)
Ethanol 81 mg/mL heating (199.3 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.61 mL 123.03 mL 246.06 mL
0.5 mM 4.92 mL 24.61 mL 49.21 mL
1 mM 2.46 mL 12.3 mL 24.61 mL
5 mM 0.49 mL 2.46 mL 4.92 mL

*The above data is based on the productmolecular weight 406.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14207
Actions Inhibitor
M. Wt 406.41
Formula C21H19FN6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1454846-35-5
Synonyms PF 06463922, PF06463922
SMILES C[[email protected]@H]1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C

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