Fig. 1 · Structure
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PF-06647263
EFNA4 ADC
PF-06647263 is an antibody-drug conjugate (ADC) that targets Ephrin-A4 (EFNA4). This compound consists of an EFNA4 antibody linked to the cytotoxic agent Calicheamicin, designed to deliver targeted anti-tumor activity. PF-06647263 has demonstrated significant tumor regression in triple-negative breast cancer (TNBC) xenograft models, making it a valuable tool for research in cancer therapeutics and targeted treatments.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1822383-65-2 |
| Applications | EFNA4 ADC |
| Molecular Weight | 147.14 kDa |
| Synonyms | anti-EFNA4-ADC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.