Fig. 1 · Structure
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PF-06649298
Citrate Transporter Inhibitor
PF-06649298 is a selective inhibitor of the sodium-coupled citrate transporter (NaCT or SLC13A5), demonstrating an IC50 value of 16.2 μM. By inhibiting citrate transport in human hepatocytes, PF-06649298 plays a critical role in the study of glucose and lipid metabolism regulation. This compound is valuable for researchers investigating metabolic disorders and therapeutic strategies targeting citrate transport pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1854061-16-7 |
| Applications | Citrate Transporter Inhibitor |
| Formula | C16H22O5 |
| Molecular Weight | 294.34 |
| SMILES | O=C(O)[C@@](O)(CCC1=CC=C(C(C)(C)C)C=C1)CC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.