PF-06821497

Catalog No.: A21388

EZH2 inhibitor

PF-06821497

PF-06821497 Chemical Structure

CAS NO. 1844849-10-0

PF-06821497 (compound 23a) is a potent, selective and orally active Enhancer of Zeste Homolog 2 (EZH2) inhibitor, with a Ki value <0.1 nM against mutant Y641N EZH2. Exhibits robust tumor growth inhibition.

Availability: In stock

Package Price Qty
1 mg
$320.00
5 mg
$960.00
10 mg
$1,600.00
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Biological Activity

PF-06821497 (compound 23a) is a potent, selective and orally active Enhancer of Zeste Homolog 2 (EZH2) inhibitor, with a Ki value <0.1 nM against mutant Y641N EZH2. Exhibits robust tumor growth inhibition.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.4 mL 106.99 mL 213.98 mL
0.5 mM 4.28 mL 21.4 mL 42.8 mL
1 mM 2.14 mL 10.7 mL 21.4 mL
5 mM 0.43 mL 2.14 mL 4.28 mL

*The above data is based on the productmolecular weight 467.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21388
Actions Inhibitor
M. Wt 467.34
Formula C22H24Cl2N2O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1844849-10-0
Synonyms PF06821497, PF 06821497
SMILES COC1=C(CN2CCC(C(Cl)=CC([[email protected]](OC)C3COC3)=C4Cl)=C4C2=O)C(NC(C)=C1)=O

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