PF-06843195 is a highly selective inhibitor of the PI3Kα isoform, exhibiting an IC50 of 18 nM in Rat1 fibroblasts. With kinase inhibition constants (Kis) of less than 0.018 nM and 0.28 nM for PI3Kα and PI3Kδ respectively, this compound effectively suppresses the PI3K/mTOR signaling pathway. PF-06843195 demonstrates significant antitumor efficacy, making it a valuable tool for research applications targeting cancer biology and therapeutic development.
PF-06843195 is a highly selective inhibitor of the PI3Kα isoform, exhibiting an IC50 of 18 nM in Rat1 fibroblasts. With kinase inhibition constants (Kis) of less than 0.018 nM and 0.28 nM for PI3Kα and PI3Kδ respectively, this compound effectively suppresses the PI3K/mTOR signaling pathway. PF-06843195 demonstrates significant antitumor efficacy, making it a valuable tool for research applications targeting cancer biology and therapeutic development.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
