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Biological Activity
PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.33 mL | 126.65 mL | 253.29 mL |
| 0.5 mM | 5.07 mL | 25.33 mL | 50.66 mL |
| 1 mM | 2.53 mL | 12.66 mL | 25.33 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.07 mL |
*The above data is based on the productmolecular weight 394.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16860 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1989620-04-3 |
| Formula | C17H16ClFN4O4 |
| M. Wt | 394.8 |
| Purity | >98% |
| Synonyms | PF06855800, PF 06855800, Prmt5-IN-2 |
| SMILES | C1=CC(=C(C=C1[[email protected]]([[email protected]@H]2[[email protected]]([[email protected]]([[email protected]@H](O2)N3C=CC4=C(N=CN=C43)N)O)O)O)F)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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