Fig. 1 · Structure
Documents & Downloads
PF-06862309
PF-06843195 Prodrug
PF-06862309 is a phosphate ester prodrug of PF-06843195, which serves as a highly selective inhibitor of PI3Kα. Upon exposure to alkaline phosphatase, PF-06862309 is hydrolyzed to release the active form, PF-06843195. This compound is particularly useful for studying breast cancer models characterized by estrogen receptor positivity, HER2 negativity, and PIK3CA mutations, providing insights into targeted therapeutic strategies in this context.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2067281-52-9 |
| Applications | PF-06843195 Prodrug |
| Formula | C20H26F3N8O7P |
| Molecular Weight | 578.44 |
| SMILES | O=[P](O)(O)OC[C@@](CN1C(OCC(F)F)=O)(CC1)NC2=NC(N3CCOCC3)=NC(C(C=N4)=CN=C4N)=C2F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.