Fig. 1 · Structure
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PF-06928215
cGAS Inhibitor
PF-06928215 is a potent inhibitor of cyclic GMP-AMP synthase (cGAS) with an IC50 value of 4.9 μM and a high binding affinity represented by a Kd of 0.2 μM. This compound is valuable for research applications focused on modulating the cGAS pathway, which plays a crucial role in innate immunity and inflammatory responses. PF-06928215 can be utilized to study the therapeutic potential of cGAS inhibition in various disease models, including autoimmune conditions and cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2378173-15-8 |
| Applications | cGAS Inhibitor |
| Formula | C20H20N4O4 |
| Molecular Weight | 380.40 |
| SMILES | OC1=CC(C2=CC=CC=C2)=NC3=C(C(N[C@H]4CCCC[C@H]4C(O)=O)=O)C=NN13 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.