Fig. 1 · Structure
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PF-07328948
BDK Inhibitor
PF-07328948 is a potent inhibitor of branch chain ketoacid dehydrogenase kinase (BDK), exhibiting an IC50 of 110 nM. This compound promotes the degradation of the branch chain ketoacid dehydrogenase (BCKDH) enzyme complex, thereby enhancing the catabolism of branched-chain amino acids (BCAAs). PF-07328948 has demonstrated beneficial effects on metabolic parameters and heart failure outcomes in rat models, making it a valuable reagent for research in metabolic disorders and cardiac health.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2936625-34-0 |
| Applications | BDK Inhibitor |
| Formula | C16H8F4O3S |
| Molecular Weight | 356.29 |
| SMILES | FC1=C(C=C(C(F)=C1OC)C2=C(C(O)=O)SC3=CC(F)=CC=C23)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.