Fig. 1 · Structure
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PF-07853578
PNPLA3 Modulator
PF-07853578 is an orally active modulator of PNPLA3, a protein linked to lipid metabolism. This compound effectively reduces the levels of the human PNPLA3-I148M mutant protein, leading to decreased hepatic triglyceride content. PF-07853578 is valuable for research into liver conditions such as cirrhosis and hepatocellular carcinoma.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 3036158-98-9 |
| Applications | PNPLA3 Modulator |
| Formula | C16H19ClF2N2O4S |
| Molecular Weight | 408.85 |
| SMILES | O=S1(N(CC[C@H]1C)[C@H]2CN(CC(F)(C2)F)C(OC3=CC=C(C=C3)Cl)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.