PF-3052334 is a potent, orally available inhibitor of HMG-CoA reductase, exhibiting an IC50 of 1.9 nM. This compound selectively inhibits cholesterol synthesis in hepatocytes with an IC50 of 0.9 nM, while displaying a significantly higher IC50 of 730 nM in muscle cells. PF-3052334 serves as a valuable tool for investigating hypercholesterolemia and related metabolic disorders.
PF-3052334 is a potent, orally available inhibitor of HMG-CoA reductase, exhibiting an IC50 of 1.9 nM. This compound selectively inhibits cholesterol synthesis in hepatocytes with an IC50 of 0.9 nM, while displaying a significantly higher IC50 of 730 nM in muscle cells. PF-3052334 serves as a valuable tool for investigating hypercholesterolemia and related metabolic disorders.
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