Fig. 1 · Structure
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PF-3837
Mps1 Inhibitor
PF-3837 is a potent Mps1 kinase inhibitor, with a Ki value of 0.33 nM and an IC50 of 5.5 nM. By inhibiting the catalytic activity of Mps1, PF-3837 disrupts cell cycle checkpoints, leading to reduced genomic stability and promoting apoptosis in cancer cells. This compound is primarily utilized in research focused on breast cancer, providing insights into cell cycle regulation and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2772910-13-9 |
| Applications | Mps1 Inhibitor |
| Formula | C21H26N8O2 |
| Molecular Weight | 422.48 |
| SMILES | N#CC1=CNC2=NC(NC3=CC=C(N4CCOCC4)N=C3C)=NC(NC(C)(CO)C)=C12 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.