Fig. 1 · Structure
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PF-3882845
MR/PR Antagonist
PF-3882845 is a potent antagonist of the mineralocorticoid receptor (MR), exhibiting high affinity with an IC50 of 2.7 nM, making it effective for conditions such as hypertension and nephropathy. Additionally, PF-3882845 also interacts with the progesterone receptor (PR), presenting a binding IC50 of 310 nM. This compound serves as a valuable tool for research in endocrine signaling and related pathophysiological studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1023650-66-9 |
| Applications | MR/PR Antagonist |
| Formula | C24H22ClN3O2 |
| Molecular Weight | 419.90 |
| SMILES | N#CC1=CC=C(N2N=C(C(C=CC(C(O)=O)=C3)=C3CC4)[C@H]4[C@@H]2C5CCCC5)C=C1Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.