PF-4

Catalog No.: A13451

BRPF1 bromodomain inhibitor

PF-4

PF-4 Chemical Structure

CAS NO. 900305-37-5

PFI-4 is a potent and selective and cell permeable BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4.

Availability: In stock

Package Price Qty
10 mg
$110.00
25 mg
$220.00
50 mg
$400.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PFI-4 is a potent and selective and cell permeable BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4.
Targets
BRPF1 BRPF2 BRPF3
80 nM7.9 μM>10μM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.29 mL 131.43 mL 262.85 mL
0.5 mM 5.26 mL 26.29 mL 52.57 mL
1 mM 2.63 mL 13.14 mL 26.29 mL
5 mM 0.53 mL 2.63 mL 5.26 mL

*The above data is based on the productmolecular weight 380.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13451
Actions No
M. Wt 380.44
Formula C21H24N4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 900305-37-5
Synonyms PF4, PF 4
SMILES [H]N(C(C1=CC=CC=C1OC)=O)C2=C(N3CCCC3)C=C(N(C)C(N4C)=O)C4=C2

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