Fig. 1 · Structure
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PF-4522654
5-HT2C Receptor Agonist
PF-4522654 is a selective agonist of the 5-HT2C receptor, exhibiting a potent EC50 of 16 nM and a Ki of 8 nM. This compound demonstrates negligible functional activity at the 5-HT2A and 5-HT2B receptors, thereby ensuring specificity. PF-4522654 is employed in research focused on stress urinary incontinence (SUI), making it a valuable tool for exploring potential therapeutic approaches in this area.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1065109-28-5 |
| Applications | 5-HT2C Receptor Agonist |
| Formula | C16H18F2N4 |
| Molecular Weight | 304.34 |
| SMILES | FC(C1=NC(CCNCC2)=C2C(NC)=N1)(C3=CC=CC=C3)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.