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Biological Activity
PF-4800567 is a potent and selective inhibitor of casein kinase 1ε (CK1ε), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM).
| In vitro | DMSO | 70 mg/mL (194.54 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.79 mL | 138.96 mL | 277.92 mL |
| 0.5 mM | 5.56 mL | 27.79 mL | 55.58 mL |
| 1 mM | 2.78 mL | 13.9 mL | 27.79 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.56 mL |
*The above data is based on the productmolecular weight 359.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21381 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1188296-52-7 |
| Formula | C17H18ClN5O2 |
| M. Wt | 359.81 |
| Purity | >98% |
| Synonyms | PF 4800567, PF4800567 |
| SMILES | NC1=C2C(N(C3CCOCC3)N=C2COC4=CC=CC(Cl)=C4)=NC=N1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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