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PF-5177624

PDK-1 Inhibitor

PF-5177624 is a selective and potent inhibitor of PDK1, a critical enzyme in the PI3K/AKT signaling pathway, which is often aberrantly activated in breast cancer. By inhibiting PDK1, PF-5177624 effectively blocks the phosphorylation of AKT at T308 and other downstream substrates, leading to reduced activation of signaling pathways associated with tumor growth. This compound has demonstrated efficacy in decreasing cell proliferation and transformation in breast cancer models, offering valuable insights for therapeutic strategies targeting dysregulated signaling in this malignancy.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1350821-45-2
Applications	PDK-1 Inhibitor
Formula	C₂₅H₂₅FN₈O₂
Molecular Weight	488.52
SMILES	O=CN1[C@@H]([C@@H](CC1)NC2=NC(C(C3=CN(C4=NC=NC(N)=C43)C(C)C)=O)=CN=C2)C5=CC=C(C=C5)F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.