Fig. 1 · Structure
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PF-5236216
CK1δ/CK1ε Inhibitor
PF-5236216 is a selective inhibitor of CK1δ and CK1ε, exhibiting IC50 values of 8 nM and 36 nM, respectively. This compound effectively prevents CK1δ and CK1ε-mediated nuclear translocation of PER3, highlighting its potential role in circadian rhythm regulation. PF-5236216's ability to penetrate the blood-brain barrier makes it useful as a tool ligand for central nervous system PET studies and offers insights into CK1-related pathways in neurological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1383376-93-9 |
| Applications | CK1δ/CK1ε Inhibitor |
| Formula | C18H15FN4O |
| Molecular Weight | 322.34 |
| SMILES | O=C1C2=C(C3=CN(C)N=C3C4=CC=C(F)C=C4)C=CN=C2CN1C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.