Fig. 1 · Structure
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PF-7006
Mps1 Inhibitor
PF-7006 is a potent inhibitor of Mps1 kinase, exhibiting a Ki of 0.27 nM and an IC50 of 2.5 nM. This compound disrupts cell cycle checkpoints by inhibiting Mps1's catalytic activity, resulting in decreased histone H3 levels and a reduction in mitotic duration, ultimately inducing apoptosis in cancer cells. PF-7006 demonstrates potential as a valuable tool in breast cancer research, particularly when combined with other agents that enhance therapeutic efficacy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2771955-09-8 |
| Applications | Mps1 Inhibitor |
| Formula | C22H26N8O2 |
| Molecular Weight | 434.49 |
| SMILES | N#CC1=CNC2=NC(NC3=CC=C(N4CCOCC4)N=C3C)=NC(NC5CCOCC5)=C12 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.