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11β-HSD1 inhibitor
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| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| 3T3-L1 | EC50 | 23.55 μM | Cytotoxicity against mouse 3T3L1 cells measured after 72 hrs by celltiter-glo luminescent cell viability assay | [PMID: 31294974] |
| HEK293 | IC50 | > 500 μM | Inhibition of 11beta-HSD2 (unknown origin) expressed in HEK293 cells using cortisone as substrate measured after 2 hrs in presence of NAD+ by HTRF assay | [PMID: 31294974] |
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 857290-04-1 |
| Applications | 11β-HSD1 inhibitor |
| Formula | C18H14N4O2S |
| Molecular Weight | 350.39 |
| SMILES | N#CC1=CC=C(C2=CC=C(S(NC3=NC(N)=CC=C3)(=O)=O)C=C2)C=C1 |
No reported solubility data are available for this product.
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
