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Biological Activity
PF-915275 is a potent, selective and orally active human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor with a Ki of 2.3 nM and an EC50 of 15 nM (in HEK293 cells).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.54 mL | 142.7 mL | 285.4 mL |
| 0.5 mM | 5.71 mL | 28.54 mL | 57.08 mL |
| 1 mM | 2.85 mL | 14.27 mL | 28.54 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.71 mL |
*The above data is based on the productmolecular weight 350.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21330 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 857290-04-1 |
| Formula | C18H14N4O2S |
| M. Wt | 350.39 |
| Purity | >98% |
| SMILES | N#CC1=CC=C(C2=CC=C(S(NC3=NC(N)=CC=C3)(=O)=O)C=C2)C=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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