Fig. 1 · Structure
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PF-DcpSi
DcpS Inhibitor
PF-DcpSi is a potent inhibitor of the mRNA decapping scavenger enzyme DcpS, with an IC50 of 0.11 nM. This reagent has been shown to improve disease phenotypes in mouse models of spinal muscular atrophy (SMA), highlighting its potential application in neurodegenerative research. PF-DcpSi serves as a valuable tool for investigating the regulatory mechanisms of mRNA stability and decay in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2092917-19-4 |
| Applications | DcpS Inhibitor |
| Formula | C16H12FN5O |
| Molecular Weight | 309.30 |
| SMILES | N#CC1=CC(F)=CC(OCC2=CC=CC3=NC(N)=NC(N)=C23)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.