Fig. 1 · Structure

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PFI-6-COOH

ENL Ligand

PFI-6-COOH is an ENL ligand that plays a pivotal role in targeting the eleven-nineteen leukemia protein. It serves as a key intermediate for the synthesis of MS41, an ENL PROTAC degrader. This compound is valuable for research applications focused on developing novel therapeutic strategies for leukemia by promoting the selective degradation of disease-related proteins.

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Specifications

Manufacturer Adooq Bioscience
Actions Ligand / Binder
CAS Number 2768514-05-0
Applications ENL Ligand
Formula C23H21N3O6
Molecular Weight 435.43
SMILES
O=C(O)C1=CC=C2CC[C@H](C2=C1)NC(C3=NOC(C4=CC(O)=C(C=C4)C(N(C)C)=O)=C3)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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