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PfPK6-IN-1

PfPK6 Inhibitor

PfPK6-IN-1 is a potent and selective inhibitor of PfPK6, exhibiting an IC50 of 0.3 μM. This compound effectively disrupts hemozoin formation, targeting a Plasmodium-specific pathway with an IC50 of 13 μM against β-hematin. PfPK6-IN-1 displays rapid and broad-spectrum anti-malarial activity, demonstrating effectiveness against both chloroquine-sensitive and resistant strains. This inhibitor is valuable for research on antimalarial mechanisms and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2417648-94-1
Applications	PfPK6 Inhibitor
Formula	C₃₄H₄₁F₃N₈O₂
Molecular Weight	650.74
SMILES	CN1CCC(C(NC2=CC(OC3=CC=C4C(N(C)C(NC5=CC=C(CN6CCN(CC)CC6)C(C(F)(F)F)=C5)=N4)=C3)=CC=N2)=O)CC1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.