PHA-543613 dihydrochloride is a selective agonist for the α7 nicotinic acetylcholine receptor (nAChR), exhibiting a Ki value of 8.8 nM. This compound is orally active and capable of penetrating the blood-brain barrier, making it suitable for in vivo studies. PHA-543613 dihydrochloride demonstrates strong selectivity for the α7 nAChR over α3β4, α1β1γδ, α4β2, and 5-HT3 receptors. It is applied in research pertinent to cognitive deficits associated with Alzheimer's disease and schizophrenia.
PHA-543613 dihydrochloride is a selective agonist for the α7 nicotinic acetylcholine receptor (nAChR), exhibiting a Ki value of 8.8 nM. This compound is orally active and capable of penetrating the blood-brain barrier, making it suitable for in vivo studies. PHA-543613 dihydrochloride demonstrates strong selectivity for the α7 nAChR over α3β4, α1β1γδ, α4β2, and 5-HT3 receptors. It is applied in research pertinent to cognitive deficits associated with Alzheimer's disease and schizophrenia.
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