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PHA-543613 dihydrochloride

α7 nAChR Agonist

PHA-543613 dihydrochloride is a selective agonist for the α7 nicotinic acetylcholine receptor (nAChR), exhibiting a Ki value of 8.8 nM. This compound is orally active and capable of penetrating the blood-brain barrier, making it suitable for in vivo studies. PHA-543613 dihydrochloride demonstrates strong selectivity for the α7 nAChR over α3β4, α1β1γδ, α4β2, and 5-HT3 receptors. It is applied in research pertinent to cognitive deficits associated with Alzheimer's disease and schizophrenia.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	478148-58-2
Applications	α7 nAChR Agonist
Formula	C₁₅H₁₉Cl₂N₃O₂
Molecular Weight	344.24
SMILES	O=C(C1=CC2=C(OC=C2)C=N1)N[C@H]3CN4CCC3CC4.[H]Cl.[H]Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.