Fig. 1 · Structure
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PHA 568487
α-7 nAchR Agonist
PHA 568487 is a selective agonist of the α-7 nicotinic acetylcholine receptor (α-7 nAchR). This compound demonstrates significant biological activity in reducing neuroinflammation and oxidative stress, making it valuable for research in neurodegenerative diseases and cognitive disorders. Its ability to rapidly penetrate the blood-brain barrier enhances its potential for therapeutic applications in central nervous system studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 527680-57-5 |
| Applications | α-7 nAchR Agonist |
| Formula | C20H24N2O7 |
| Molecular Weight | 404.41 |
| SMILES | OC(/C=C/C(O)=O)=O.O=C(C1=CC=C(OCCO2)C2=C1)N[C@@H]3C4CCN(CC4)C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.