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PHD-1-IN-2

PHD-1 Inhibitor

PHD-1-IN-2 is a potent inhibitor of hypoxia-inducible factor prolyl hydroxylase domain 1 (PHD-1), exhibiting an IC50 value of 0.07 μM. This compound serves as a substrate for MDR1 in monolayer assays using MDR1-MDCK cells. PHD-1-IN-2 is valuable for investigating mechanisms related to ischemia, inflammatory responses, and neurodegenerative diseases, including inflammatory bowel disease and ischemia-reperfusion injury. Its ability to modulate PHD-1 activity makes it a key tool in related research fields.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2009344-53-8
Applications	PHD-1 Inhibitor
Formula	C₁₆H₁₃N₅O
Molecular Weight	291.31
SMILES	N#CC=1C=CC(C2=CC(=CC3=NC=NN32)NC(=O)C)=C(C1)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.