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PHD-IN-3

PHD Inhibitor

PHD-IN-3 is a potent inhibitor of prolyl hydroxylase domain (PHD) enzymes, demonstrating oral bioavailability. This compound is particularly relevant for research in anemia associated with chronic kidney disease, as it modulates hypoxia-inducible factor (HIF) stability, enhancing erythropoiesis. Its mechanism of action makes it a valuable tool for studying the physiological and pathological roles of HIF in various cellular contexts.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2924181-77-9
Applications	PHD Inhibitor
Formula	C₂₀H₁₈N₆O₃
Molecular Weight	390.40
SMILES	O[C@@H]1CCN(C1)C2=NC3=C(C(O)=C(N=C3)C(NCC4=CN=C(C=C4)C#N)=O)C=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.