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PHD-IN-5

PHD Inhibitor

PHD-IN-5 (ISM4808) is an orally active inhibitor of prolyl hydroxylase domain (PHD) enzymes. This compound effectively enhances hypoxia-inducible factor (HIF) stability, which is critical for regulating erythropoiesis and iron metabolism. PHD-IN-5 is primarily utilized in research concerning anemia, particularly in the context of chronic kidney disease, offering insights into potential therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2924181-95-1
Applications	PHD Inhibitor
Formula	C₂₁H₁₈N₆O₃
Molecular Weight	402.41
SMILES	O=C(C1=C(O)C2=CC=C(N3[C@@H](C4)CO[C@@H]4C3)N=C2C=N1)NCC5=CN=C(C#N)C=C5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.