Fig. 1 · Structure
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PHD2-IN-1
PHD2 Inhibitor
PHD2-IN-1 is a potent inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (PHD2), exhibiting an IC50 of 22.53 nM. This compound is primarily utilized in research related to anemia, providing valuable insights into hypoxia signaling pathways and related physiological responses. Its oral bioavailability enhances its application in various preclinical studies on erythropoiesis and oxygen homeostasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2768219-28-7 |
| Applications | PHD2 Inhibitor |
| Formula | C21H23ClN4O5 |
| Molecular Weight | 446.88 |
| SMILES | ClC1=CC=C(NCC(N2CCC(C3=CN=C(C(NCC(O)=O)=O)C(O)=C3)CC2)=O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.